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Protocol for delivery of intraoperative immunotherapy to mice by surgical debulking of subcutaneous tumors

Pre-clinical studies developing novel therapies to prevent cancer recurrence require appropriate surgical models. Here, we present a protocol for surgical debulking of subcutaneous tumors in mice, which allows for intraoperative application of immunotherapy-loaded biomaterials. 

Citation:
Rwandamuriye FX, Vitali B, Schreurs J, Wang T, Barrick E, Iyer KS, Lesterhuis WJ, Zemek RM, Wylie B. Protocol for delivery of intraoperative immunotherapy to mice by surgical debulking of subcutaneous tumors. STAR Protoc. 2024;5(2):102948.

Keywords:
Cancer; Immunology; Model Organisms

Abstract:
Pre-clinical studies developing novel therapies to prevent cancer recurrence require appropriate surgical models. Here, we present a protocol for surgical debulking of subcutaneous tumors in mice, which allows for intraoperative application of immunotherapy-loaded biomaterials.