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Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes

Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response. 

Citation:
Kidman J, Zemek RM, Sidhom JW, …… Fear VS, Forbes CA, Chopra A, ….. de Jong E, Holt RA, Jones M, Millward MJ, Lassmann T, Forrest ARR, .…. Lesterhuis WJ, Chee J. Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes. OncoImmunology. 2024;13(1).

Keywords:
Immune checkpoint therapy; T cell receptor (TCR) sequencing; T cells; immune repertoire; machine learning; tumour-infiltrating lymphocytes

Abstract:
Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response.