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The Development of a Chocolate-Based Chewable Tablet of Prednisolone—Enhancing the Palatability of Steroids for Pediatric Use

Oral liquid prednisolone medications have poor acceptance among paediatric patients due to ineffective masking of the bitterness taste of prednisolone. This study aimed to develop a child-friendly prednisolone tablet using a patented chewable chocolate-based delivery system previously applied successfully to mask the bitterness tastes of midazolam and tramadol.

Citation:
Yoo O, Tang E, Hossain ML, von Ungern-Sternberg BS, Sommerfield D, Heath C, Hauser N, Khan RN, Locher C, Nguyen M, Lim LY. The Development of a Chocolate-Based Chewable Tablet of Prednisolone—Enhancing the Palatability of Steroids for Pediatric Use. Pharmaceutics. 2024;16(8).

Keywords:
Chocolate-based delivery system; medication adherence; paediatric formulation; prednisolone; taste masking

Abstract:
Oral liquid prednisolone medications have poor acceptance among paediatric patients due to ineffective masking of the bitterness taste of prednisolone. This study aimed to develop a child-friendly prednisolone tablet using a patented chewable chocolate-based delivery system previously applied successfully to mask the bitterness tastes of midazolam and tramadol.