FDA-approved disulfiram as a novel treatment for aggressive leukemia

Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach.

Citation:
Karsa M, Xiao L, Ronca E, Bongers A, ……. Cheung LC, Kotecha RS, Sutton R, et al. FDA-approved disulfiram as a novel treatment for aggressive leukemia. J Mol Med. 2024;102(4):507-519

Keywords:
Auranofin; Disulfiram; Leukemia; Oxidative stress; Repurposing

Abstract:
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach.