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Rebooting the anal sphincter: A retrospective cohort of children with intractable constipation receiving intrasphincteric botox injections

Chronic childhood constipation is a common problem that severely impacts quality of life. Recently, the efficacy of intrasphincteric botulinum toxin (botox) injection in breaking the cycle of constipation has been demonstrated. The current study aims to investigate response rate to treatment, symptom and examination finding associations, and identify associations between patient characteristics and outcome.

Citation:
Uden L, Jiwane M, Sharma JR, Sharma A, Evans D, von Ungern-Sternberg BS, Gera P. Rebooting the anal sphincter: A retrospective cohort of children with intractable constipation receiving intrasphincteric botox injections. Journal of Pediatric Surgery Open. 2024;7:100147.

Keywords:
Botulinum toxin (botox)Intractable constipationRectal ectasiaEncopresisDentate lineAnal cushion of veins

Abstract:
Chronic childhood constipation is a common problem that severely impacts quality of life. Recently, the efficacy of intrasphincteric botulinum toxin (botox) injection in breaking the cycle of constipation has been demonstrated. The current study aims to investigate response rate to treatment, symptom and examination finding associations, and identify associations between patient characteristics and outcome.