Could late-latent syphilis be treated with a single subcutaneous infusion of long-acting penicillin?

Syphilis is an important global health threat and little has changed in its treatment since the mid-20th century. For late-latent or syphilis infection of unknown duration, the standard treatment of multiple intramuscular injections of benzathine penicillin G (BPG) are associated with significant pain and distress to clients and caregivers, negatively impacting on treatment completion.

Citation:
Hla TK, Salman S, Kado J, Moore BR, Manning L. Could late-latent syphilis be treated with a single subcutaneous infusion of long-acting penicillin? Sex Health. 2024;21(2).

Keywords:
Anti-bacterial agents; therapeutic use; infusions; drug therapy; penicillin G Benzathine; Syphilis; injections

Abstract:
Syphilis is an important global health threat and little has changed in its treatment since the mid-20th century. For late-latent or syphilis infection of unknown duration, the standard treatment of multiple intramuscular injections of benzathine penicillin G (BPG) are associated with significant pain and distress to clients and caregivers, negatively impacting on treatment completion.