The longitudinal microbial and metabolic landscape of infant cystic fibrosis: the gut-lung axis

In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome.

Citation:
Frayman KB, Macowan M, Caparros-Martin J, Ranganathan SC, Marsland BJ. The longitudinal microbial and metabolic landscape of infant cystic fibrosis: the gut-lung axis. Eur Respir J. 2024;63(5).

Keywords:
Cystic fibrosis; antibacterial agents; therapeutic use; microbiology; bronchoalveolar lavage; case control studies; lung; metabolomics; RNA

Abstract:
In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome.