Validation and Application of a Dried Blood Spot Amoxicillin Assay

Dried blood spot (DBS) antibiotic assays can facilitate pharmacokinetic (PK) investigations in situations where venous blood sampling is logistically and/or ethically challenging. The aim of this study was to establish, validate and demonstrate the application of a DBS amoxicillin assay for PK studies in vulnerable populations.

Citation:
Page-Sharp M, Yoo O, Salman S, Davis TME, Moore BR, Manning L, Batty KT. Validation and Application of a Dried Blood Spot Amoxicillin Assay. Chromatographia. 2024:87(7-8);493-501.

Keywords:
Amoxicillin; dried blood spots; LC–MS/MS; pharmacokinetics

Abstract:
Dried blood spot (DBS) antibiotic assays can facilitate pharmacokinetic (PK) investigations in situations where venous blood sampling is logistically and/or ethically challenging. The aim of this study was to establish, validate and demonstrate the application of a DBS amoxicillin assay for PK studies in vulnerable populations.