Genomic characterization of clinically significant blood group variants in Aboriginal Australians

Hematological disorders are often treated with blood transfusions. Many blood group antigens and variants are population-specific, and for patients with rare blood types, extensive donor screening is required to find suitable matches for transfusion. There is a scarcity of knowledge regarding blood group variants in Aboriginal Australian populations, despite a higher need for transfusion due to the higher prevalence of renal diseases and anemia.

Citation:
Jadhao S, Davison C, Roulis E, ……. Brown A, Perry M, et al. Genomic characterization of clinically significant blood group variants in Aboriginal Australians. Blood Transfusion. 2024;22(6):464-74.

Keywords:
Epidemiology; Australian Aboriginal and Torres Strait Islander Peoples; genetics; blood group antigens; pregnancy

Abstract:
Hematological disorders are often treated with blood transfusions. Many blood group antigens and variants are population-specific, and for patients with rare blood types, extensive donor screening is required to find suitable matches for transfusion. There is a scarcity of knowledge regarding blood group variants in Aboriginal Australian populations, despite a higher need for transfusion due to the higher prevalence of renal diseases and anemia.