B cell epitope mapping: The journey to better vaccines and therapeutic antibodies

B-cell epitope mapping is an approach that can identify and characterise specific antigen binding sites of B-cell receptors and secreted antibodies. The ability to determine the antigenic clusters of amino acids bound by B-cell clones provides unprecedented detail that will aid in developing novel and effective vaccine targets and therapeutic antibodies for various diseases.

Citation:
De Leon AJ, Tjiam MC, Yu Y. B cell epitope mapping: The journey to better vaccines and therapeutic antibodies. Biochim Biophys Acta Gen Subj. 2024;1868(10).

Keywords:
Antibody; B-cell; ELISA; Epitope; Peptide

Abstract:
B-cell epitope mapping is an approach that can identify and characterise specific antigen binding sites of B-cell receptors and secreted antibodies. The ability to determine the antigenic clusters of amino acids bound by B-cell clones provides unprecedented detail that will aid in developing novel and effective vaccine targets and therapeutic antibodies for various diseases.