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Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade

Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4, programmed cell death protein/ligand 1 are approved for treatment of multiple cancer types. 

Citation:
Principe N, Phung AL, Stevens KLP, ……. Wylie B, Tilsed CM, Sheikh F, Orozco Morales ML, Kidman J, …….. McDonnell AM, Lesterhuis WJ, Chee J. Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade. J Immunother Cancer. 2024;12(9).

Keywords:
Chemotherapy; Combination therapy; Immune checkpoint inhibitors; T-lymphocytes

Abstract:
Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4, programmed cell death protein/ligand 1 are approved for treatment of multiple cancer types.