Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions

Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.

Citation:
Lamoureux AA, Fisher MJ, Lemelle L, …….. Gottardo NG, Dholaria H, et al.. Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions. Clin Cancer Res. 2025;31(3):561-72.

Keywords:
Central nervous systems; genetics; mortality; pathology; therapy; gene fusion; glioma;

Abstract:
Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.