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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179

OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies to target this tumor cell population.

Citation:
Li Y, Lim C, Dismuke T, Malawsky DS, ……..Stein G, Piper M, Johns TG, Sokolsky-Papkov M, et al. Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179. Nat Commun. 2025;16(1).

Keywords:
Apoptosis; drug effects; cell line; tumour; cell proliferaton; neoplasms; genetics; metabolism; antagonists; hedgehog proteins; medulloblastoma

Abstract:
OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies to target this tumor cell population.