The histone demethylase dLsd1 regulates organ size by silencing transposable elements

The specific role of chromatin modifying factors in the timely execution of transcriptional changes in gene expression to regulate organ size remains largely unknown. Here, we report that in Drosophila melanogaster depletion of the histone demethylase dLsd1 results in the reduction of wing size. dLsd1 depletion affects cell proliferation and causes an increase in DNA damage and cell death.

Citation:
Selmi I, Texier M, Aguirrenbegoa M, Merce C, Fraisse-lepourry L, et al. The histone demethylase dLsd1 regulates organ size by silencing transposable elements. Commun Biolog. 2025;8(1).

Keywords:
Cell proliferation; genetics; dna; transposable elements; drosophila proteins; metabolism; gene silencing; organ size

Abstract:
The specific role of chromatin modifying factors in the timely execution of transcriptional changes in gene expression to regulate organ size remains largely unknown. Here, we report that in Drosophila melanogaster depletion of the histone demethylase dLsd1 results in the reduction of wing size. dLsd1 depletion affects cell proliferation and causes an increase in DNA damage and cell death.