Antibody responses against influenza A decline with successive years of annual influenza vaccination

Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021.

Citation:
Sullivan SG, Khvorov A, Carolan L, ……… Blyth CC, Macnish M, Cheng AC, et al. Antibody responses against influenza A decline with successive years of annual influenza vaccination. npj Vaccines. 2025;10(1).

Abstract:
Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021.