Maternal concentrations of perfluoroalkyl sulfonates and alterations in white matter microstructure in the developing brains of young children

Maternal exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to child neurodevelopmental difficulties. Neuroimaging research has linked these neurodevelopmental difficulties to white matter microstructure alterations, but the effects of PFAS on children's white matter microstructure remains unclear.

Citation:
England-Mason G, Reardon AJF, Reynolds JE, Grohs MN, et al. Maternal concentrations of perfluoroalkyl sulfonates and alterations in white matter microstructure in the developing brains of young children. Environ Res. 2025;267.

Keywords:
APrON; Neuroimaging; PFHxS; PFOS; Perfluoroalkyl acids; Pregnancy; White matter

Abstract:
Maternal exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to child neurodevelopmental difficulties. Neuroimaging research has linked these neurodevelopmental difficulties to white matter microstructure alterations, but the effects of PFAS on children's white matter microstructure remains unclear.