Early markers of adult symptoms of depression and anxiety in the Raine Study

Early intervention offers the potential to mitigate adult mental illness; however, trials spanning decades present significant challenges, necessitating predictive early markers useable in trial settings. We hypothesised that parent evaluation using the child behaviour checklist (CBCL) total problem score at age two years predicted adult depressive and anxious symptoms and explored other potential parent ratings.

Citation:
Byg LM, Wang CA, Whitehouse AJO, Pennell CE. Early markers of adult symptoms of depression and anxiety in the Raine Study. J Affective Disord. 2025;381:166-73.

Keywords:
Anxiety; Child Behaviour Checklist; Depression; Depression, Anxiety and Stress Scale; Early markers

Abstract:
Early intervention offers the potential to mitigate adult mental illness; however, trials spanning decades present significant challenges, necessitating predictive early markers useable in trial settings. We hypothesised that parent evaluation using the child behaviour checklist (CBCL) total problem score at age two years predicted adult depressive and anxious symptoms and explored other potential parent ratings.