Investigators
Daniel Oakes, Carla Puca, Yue Wu, Charlie McLeod, Paige Wood-Kenney, Rebecca Pavlos, Meredith Borland, Christopher Blyth
Project description
Patient (or parent/carer proxy) Reported Outcomes (PROs) are those reported from a patient perspective, capturing how they feel, function, or survive. There have been global calls for PRO measures (PROMs) or questionnaires that describe the person-centred outcomes that matter most to those burdened by disease. PRO/PROMs are now recommended for use in clinical trials to ensure outcomes are both clinically meaningful and important to patients.
Most children with Acute Lower Respiratory Infections (ALRIs) are managed in community settings or emergency departments, rather than within hospitals. To use clinical trials to inform gaps in ALRI knowledge and improve ALRI outcomes, we need suitable endpoints for use in these settings.
Using knowledge gained from systematic review, evidence-informed ALRI models, and prospective ALRI registry data, this application will bring together clinical and community stakeholders to inform the development of a validated PROM, suitable for use within the Pragmatic Adaptive Trial for Respiratory Infections in Children (PATRIC) and other ALRI intervention studies.
External collaborators
- The Paediatric Research in Emergency Departments International Collaborative (PREDICT) network
- Emergency Department and Department of Infectious Diseases at Perth Children’s Hospital (PCH)
- The University of Sydney (USYD)
- The University of Western Australia (UWA)
Funders
This work is funded by the Wesfarmers Centre for Vaccines & Infectious Diseases