Investigators: Alison McDonnell, Jesse Armitage, Jason Waithman, Hannah Newnes
Project description
Tissue resident memory T cells are cancer killing immune cells that have emerged as key players in immune-mediated control of solid cancers, as well as being markers of prognosis and predictors of response to immunotherapy. In addition, we recently demonstrated that tissue resident memory T cells can maintain cancer cells in a state of dormancy. This suggests that tissue resident memory T cells are critical in controlling the growth and progression of solid tumours. We are using single cell sequencing and spatial transcriptomics to understand how these cancer killing tissue resident memory T cells put cancer cells to sleep, and how they become activated to kill cancer cells so that we can develop new therapies that will boost their cancer killing power.
Collaborators: Kai Plunkett, Jonathon Chee, Nicola Principe, Melanie McCoy, Peter Lau, Abha Chopra, Mark Watson, Anna Nowak
Partners
- Cancer Council WA
- icare Dust Diseases Care