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Directing immune development to curb sky-rocketing diseaseOnce upon a time it was infectious diseases like polio, measles or tuberculosis that most worried parents. With these threats now largely under control, parents face a new challenge – sky-rocketing rates of non-infectious diseases such as asthma, allergies and autism.
Research
Epstein–Barr virus infection, B-cell dysfunction and other risk factors converge in gut-associated lymphoid tissue to drive the immunopathogenesis of multiple sclerosis: a hypothesisMultiple sclerosis is associated with Epstein–Barr virus (EBV) infection, B-cell dysfunction, gut dysbiosis, and environmental and genetic risk factors, including female sex.
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Direct infant UV light exposure is associated with eczema and immune developmentThis study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema
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Sun-immune connectionExposure to ultraviolet radiation damages skin cell DNA but skin cancers develop because ultraviolet radiation also affects the immune system
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Vitamin D C3-epimer levels are proportionally higher with oral vitamin D supplementation compared to ultraviolet irradiation of skin in mice but not humansThe proportion of 25(OH)D3 that undergoes epimerization is greater with oral vitamin D3 supplementation than exposure to UVR in mice, but not in humans
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Molecular actions of Vitamin D in reproductive cell biologyThe aim of this work is to review current metabolic and molecular aspects of the VitD-VitD receptor axis in reproductive medicine
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Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.We propose that this system provides a model for the differentiation and adaptation of monocytes entering the intestinal lamina propria.
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Prostaglandin E2 imprints a long-lasting effect on dendritic cell progenitors in the bone marrowInjection of BM-differentiated DCs from nonchimeric mice restored the reduced immune responses of PGE2-chimeric mice.
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Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the AbsenceVitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator.
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Dendritic cells and multiple sclerosis: Disease, tolerance and therapyMultiple sclerosis (MS) is a devastating neurological disease that predominantly affects young adults resulting in severe personal and economic impact.