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Lowering Australia's defence against infectious diseasesAustralia's defence, infectious diseases
Research
MEIS proteins as partners of the TLX1/HOX11 oncoproteinAberrant expression of the TLX1/HOX11 proto-oncogene is associated with a significant subset of T-cell acute lymphoblastic leukemias...
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Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+Direct UV irradiation of dendritic cells and Langerhans cells reduces their Ag presenting ability. However, the effects of UV on CD11c(+) cells located...
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Narrowing the broader autism phenotype: A study using the Communication ChecklistThis study investigated whether the Communication Checklist - Adult (CC-A) could identify subtypes of social and communication dysfunction in autism probands an
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Innate immunity in human newborn infants: prematurity means more than immaturityNeonates, particularly those born prematurely, are exquisitely vulnerable to life-threatening infections. This increased susceptibility to infection...
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Does genetic regulation of IgE begin in utero?Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allerg
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Reproduction in females: the role of the early life environmentThere is now compelling evidence that long-term health and physiological function are modified by events that occur early in life and involve interactions...
News & Events
The Kids researchers awarded Raine Medical Research Foundation fundingCongratulations to three The Kids Research Institute Australia researchers, who have been awarded funding from the Raine Medical Research Foundation.
Research
Glucose enhancement of human memory:The brain relies upon glucose as its primary fuel. In recent years, a rich literature has developed from both human and animal studies indicating...
News & Events
New imaging equipment to boost children's cancer researchA cutting edge cancer imaging facility will help specialist children's cancer researchers at Perth's Telethon Institute for Child Health Research.
Research
A case-crossover analysis of traffic-related air pollution and emergency department presentations for asthma in PerthTo determine whether changes in 24-hour average background ozone (O₃), nitrogen dioxide (NO₂), carbon monoxide (CO) and particulates < 10 μm (PM₁₀) increase the
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Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphomaIL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition
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Research as intervention: Engaging silenced voicesThe emergence of Indigenous researchers into the public health research sector presents a challenge to what have traditionally been Western-based research...
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Germline Elongator mutations in Sonic Hedgehog medulloblastomaGenetic predisposition to proteome instability may be a determinant in the pathogenesis of paediatric brain cancers
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Coffee and tea consumption during pregnancy and risk of childhood acute myeloid leukemia: A Childhood Leukemia International Consortium (CLIC) studyWe investigated the potential association of maternal coffee and tea consumption during pregnancy with childhood acute myeloid leukemia risk
Formative research undertaken by The Kids Research Institute Australia has helped inform tough new laws introduced by the Federal Government to reduce the harm caused by vapes.
Research
Editorial: Insights Into Biomarkers, Cytokines, and Chemokines in Skin CancerOur current Research Topic highlights the complexity of the relationship between the skin, immune system and skin cancer
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Dendritic cells and cancer: From biology to therapeutic interventionIn this review, we discuss the different subsets of tumor-infiltrating dendritic cells and their role in anti-tumor immunity
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CD8+XCR1neg Dendritic Cells Express High Levels of Toll-Like Receptor 5 and a Unique Complement of Endocytic ReceptorsOur data demonstrate that CD8+XCR1neg DCs possess a unique pattern of endocytic receptors and a restricted TLR profile that is particularly enriched for TLR5