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Research

Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo

The objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo.

Research

Ndrg1 in development and maintenance of the myelin sheath

CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability, caused by mutations...

Research

Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny

We sought to explore whether allergic children show differences in microbial Toll-like receptor (TLR)-mediated responses over their first 5 years of life.

News & Events

New Home for ORIGINS

The Kids Joondalup will be the new home for the ORIGINS research and data teams

The Natural History of Scoliosis in Females with Rett Syndrome

We described the occurrence of scoliosis in Rett syndrome, how it develops and how it is influenced by the individual's age, mutation type, and walking ability.

Research

PRAGMA-CF. A Quantitative Structural Lung Disease Computed Tomography Outcome in Young Children with Cystic Fibrosis

Chest computed tomography (CT) is the gold standard for demonstrating cystic fibrosis (CF) airway disease. However, there are no standardized outcome...

Research

Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective

The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children

Research

QuantSeq. 3′ Sequencing combined with Salmon provides a fast, reliable approach for high throughput RNA expression analysis

QuantSeq, coupled with a fast quantification method such as Salmon, should provide a viable alternative to traditional RNA-Seq in many applications

Don’t stop her now – Gina’s having a ball

Despite the risk of having a hypo (low blood glucose levels), Gina said she refused to let T1D stop her from exercising.

Research

Empowering Social Competence: A Scoping Review of Digital Social Skills Training Interventions

Effective social skills are essential for functional social support, help-seeking, and resource access. Digital social skills training plays a key role in empowering individuals to develop social competence, improve access to various support and resources, and enhance locus of control through dynamic media.