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News & Events
2024 Seed Funding Grants now openApplications are now open for our 2024 Seed Funding grants.
News & Events
Telethon grant supporting families navigating early-stage type 1 diabetesThanks to the generous support of West Australians, new funding from Channel 7’s Telethon Trust will help develop a much-needed clinical pathway to support families with kids who have early-stage type 1 diabetes (T1D).
News & Events
NovoRapid urgent product defect alertWe have been advised by Novo Nordisk, the manufacturer of NovoRapid, that some circulating Novorapid cartridges may have small circular
News & Events
Student scholarship opportunities now openWe are excited to announce that applications are now open for our PhD scholarships and our Honours/Masters scholarships to support students pursuing
News & Events
A recipe for success in managing type 1 diabetes for teenagersAn innovative cooking program, the first of its kind in Australia, is being offered at Perth Children’s Hospital, combining nutrition education and practical cooking skills for teenagers living with type 1 diabetes (T1D).
Research
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastomaMedulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.
Research
Comparing Web-Based Mindfulness With Loving-Kindness and Compassion Training for Promoting Well-Being in Pregnancy: Protocol for a Three-Arm Pilot Randomized Controlled TrialPromoting psychological well-being and preventing distress among pregnant women is an important public health goal. In addition to adversely impacting the mother's health and well-being, psychological distress in pregnancy increases the risk of poor pregnancy outcomes, compromises infant socioemotional development and bonding, and heightens maternal and child vulnerability in the postpartum period. Mindfulness and compassion-based interventions show potential for prevention and early intervention for perinatal distress.
Research
Human genetics of leishmania infectionsGWAS results provide firm confirmation for the importance of antigen presentation and the regulation of IFNγ in determining the outcome of Leishmania infections
Research
Clinical description and outcomes of Australian children with invasive group a streptococcal diseaseInvasive group A streptococcal infection in Australian children is frequently severe and has a high long-term morbidity burden
Research
Structural determinants of long term functional outcomes in young children with cystic fibrosisChest CT identifies children at an early age who have adverse long-term outcomes