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Research
Vagus nerve stimulation for the treatment of refractory epilepsy in the CDKL5 Deficiency DisorderOur study suggests that vagus nerve stimulation is a generally safe and effective adjunct treatment for CDKL5-associated epilepsy
News & Events
Guest article: How my son found perspective after a life-changing car accidentJosh Forde, 18, with mum Karen, who shares how her fears turned to
Research
What effect does regular exercise have on oxidative stress in people with Down syndrome? A systematic review with meta-analysesThere remains uncertainty about the effect of exercise on oxidative stress in people with Down syndrome
News & Events
Bridging the gap for Aboriginal familiesResearchers on the Embrace parenting program Rebeka Morrison, Nita Alexander, and Aysa Bahar Arjmand.
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Epigenetic dysregulation of host gene expression in Toxoplasma infection with specific reference to dopamine and amyloid pathwaysOur results provide a possible functional link between Toxoplasma gondii infection and congenital/early life and adult neurological clinical signs
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Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbationsOur findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations
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Rheumatic Heart Disease Worldwide: JACC Scientific Expert PanelThe authors present a variety of pressing clinical research questions on optimal RHD prevention and advanced care
News & Events
2024 Seeding Grant winners announcedEmbrace 2024 Seeding Grant winners (clockwise from top left): Dr Penelope Strauss, Dr Renee Teal, Dr Melissa Licari, Dr Vincent Mancini
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Food environments and dietary intakes among adults: Does the type of spatial exposure measurement matter? A systematic reviewAvailability measures may produce significant and greater effect sizes than accessibility measures
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Topical antibiotics with steroids for chronic suppurative otitis mediaTo assess the effects of adding a topical steroid to topical antibiotics in the treatment of people with chronic suppurative otitis media
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Cellular and molecular mechanisms of vitamin D in food allergyEpidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis
News & Events
Writing our story for Wear It Purple DayEmbrace @ The Kids Research Institute Australia celebrates Wear It Purple Day with Rio Tinto
Research
β-Lactamase Tools for Establishing Cell Internalization and Cytosolic Delivery of Cell Penetrating PeptidesThe β-lactamase assays provide compatible tools for functional characterization of CPP activity and the delivery of biological cargos into cells
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Large-Scale Structural Variation Detection in Subterranean Clover Subtypes Using Optical MappingThe accuracy of structural variations detection by Bionano optical mapping is highly dependent on the quality of reference genomes and the density of selected nickases
News & Events
Embrace-linked psychiatrist calls for greater coordinationAssociate Professor Pradeep Rao called for more hope among clinicians and young people alike when accessing services.
Research
“I don't really exist here”: A reflexive thematic analysis of dissociative symptoms described by adolescents and their parents and cliniciansDissociative symptoms are associated with a range of negative outcomes, yet little is understood about how adolescents experience dissociation in their daily lives. This study aimed to describe adolescents’ dissociative symptoms from the perspective of adolescents, their parents, and their treating clinicians.
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Improving Outcome Reporting in Paediatric Airway Management in Clinical Trials (IMPACT): A Study Protocol for Core Outcomes and Clinical EndpointsAlthough clinical trials are fundamental to advancing evidence-based practice, significant heterogeneity in outcome reporting poses a considerable challenge to the validity of systematic reviews. This inconsistency impedes the ability to compare, synthesise and interpret research findings effectively. In the field of paediatric airway management, this issue is particularly relevant because of the low incidence of critical events and the related high morbidity and mortality. The issue of inadequate and variable outcome reporting in clinical trials has been widely acknowledged, necessitating initiatives to enhance the quality of future research.
Research
Quantitative measures of subjective wellbeing for adolescents: a scoping review and synthesis of comparable dataEfforts to promote adolescent wellbeing are of increasing global interest. Although the ability to measure wellbeing is essential for identifying disparities between and within populations, and for tracking progress in improving wellbeing, the best way to measure this elusive concept in adolescents is unclear.
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Experiences and Recognition of Intimate Partner Violence among a Community-Sample of LGBTIQA + People in Western AustraliaLGBTIQA + people experience intimate partner violence (IPV) at higher rates than non-LGBTIQA + people but under-utilize professional support services, and the reasons for this are poorly understood. This study examined IPV experiences, recognition of IPV, service utilization, and support needs among a self-selected sample of 523 LGBTIQA + adults in Western Australia.
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Indigenous infants in remote Australia retain an ancestral gut microbiome despite encroaching Westernization
Studies of traditional Indigenous compared to 'Western' gut microbiomes are underrepresented, and lacking in young children, limiting knowledge of early-life microbiomes in different cultural contexts. Here we analyze the gut metagenomes of 50 Indigenous Australian infants (median age