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Research
Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cellsMature B cells, CR2/CD21 transcription proceeds from a focused TSS regulated by a non-consensus TATA box, an initiator element and downstream promoter element
Research
Phylomer Libraries: A Rich Source of Peptide Hits in Phenotypic and Target Directed ScreensThe poor hit rates associated with conventional random peptide libraries present formidable challenges in genetic screening formats with limited throughput.
People
Dr Charlie McLeodDr Charlie McLeod is a Deputy Head at the Wesfarmers Centre of Vaccines and Infectious Diseases, based at The Kids Research Institute Australia, and of a member of the Centre's Infectious Diseases Implementation Research (IDIR) team.
Research
Gestational age as a predictor for subsequent preterm birth in New South Wales, AustraliaThere is no validated evidence base on predictive ability and absolute risk of preterm birth by gestational age of the previous pregnancy. We conducted a retrospective cohort study of mothers who gave birth to their first two children in New South Wales, 1994-2016. For each week of final gestational age of the first birth, we calculated relative and absolute risks of subsequent preterm birth.
Research
A multifaceted approach increased staff confidence to develop outside of school hours care as a health promoting settingOutside-of-school-hours-care (OSHC) services are well positioned to influence the health behaviours of 489, 800 Australian children, and are an important setting for health promotion given the current rates of childhood overweight and obesity and associated health risks. OSHC Professionals are ideally placed to become positive influencers in this setting, although they may require training and support to confidently perform this role.
Research
Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic DiseaseIn this concept paper, we discuss multiomic approaches to studying immune dysregulation and highlight some of the challenges and opportunities
Research
Epidemiology of intussusception before and after rotavirus vaccine introduction in FijiThe incidence of intussusception pre-rotavirus vaccine in Fiji is low
Research
Use of bevacizumab as a single agent or in adjunct with traditional chemotherapy regimens in children with unresectable or progressive low-grade gliomaBevacizumab is well tolerated and appears most effective for rapid tumor control to preserve vision and improve morbidity
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Reconstructing the early global dynamics of under-ascertained COVID-19 cases and infectionsAsymptomatic or subclinical SARS-CoV-2 infections are often unreported, which means that confirmed case counts may not accurately reflect underlying epidemic dynamics. Understanding the level of ascertainment (the ratio of confirmed symptomatic cases to the true number of symptomatic individuals) and undetected epidemic progression is crucial to informing COVID-19 response planning, including the introduction and relaxation of control measures.
Research
Making a difference: Engaging both hearts and minds in research practiceThis paper discusses the findings and the research process undertaken thus far for the Looking Forward Aboriginal Mental Health Project.