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There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy.
Atopy and asthma are commonly initiated during early life, and there is increasing interest in the development of preventive treatments for at-risk children.
These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention
Our findings demonstrate the utility of unsupervised analysis in elucidating heterogeneity in asthma pathogenesis
GWAS analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis suggested shared genetic mechanisms across rhinitis-related traits
Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure
We identified new asthma loci, found new associations at loci implicated in the comorbidity of asthma plus hay fever and confirmed nine known loci.
Identify entrenched areas of asthma management and treatment in which progress has stalled and to challenge current principles
The present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric acute respiratory infection (ARI).
We sought to assess whether the trajectory to asthma begins already at birth and whether epigenetic mechanisms, contribute to asthma inception.