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Is cellular heterogeneity merely a confounder to be removed from epigenome-wide association studies?

DNA methylation is a very sensitive measure of cell fate mix and therefore reveals much about underlying disease etiology including aspects of causation.

Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes

Genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment

Somatosensory discrimination intervention improves body position sense and motor performance in children with hemiplegic cerebral palsy

The intervention group improved in goal performance, proprioception, and bimanual hand use and maintained improvement at 6-mo follow-up.

Meningococcal serogroup B-specific responses after vaccination with bivalent rLP2086

Assessment of the persistence of bactericidal antibodies up to 4 years after a three-dose schedule of bivalent rLP2086

Cyberbullying and the role of the law in Australian schools: Views of senior officials

Opinions of employees from the education and legal systems, regarding their perceptions of the role of the law and cyberbullying in Australian schools

Longitudinal analysis of respiratory outcomes among bauxite exposed workers in western Australia

This study investigated any associations between cumulative bauxite exposure and respiratory symptoms.

The Immune Response to Skin Trauma Is Dependent on the Etiology of Injury in a Mouse Model of Burn and Excision.

This article investigates the impact of burn & excisional injury on the immune system.

The social and emotional well-being and mental health implications for adolescents transitioning to secondary boarding school

This paper explores the social and emotional wellbeing and mental health complexities for Western Australian adolescents when they transition to boarding school

Paediatric Medicinal Formulation Development: Utilising Human Taste Panels and Incorporating Their Data into Machine Learning Training

This review paper explores the role of human taste panels and artificial neural networks (ANNs) in taste-masking paediatric drug formulations. Given the ethical, practical, and regulatory challenges of employing children, young adults (18-40) can serve as suitable substitutes due to the similarity in their taste sensitivity. Taste panellists need not be experts in sensory evaluation so long as a reference product is used during evaluation; however, they should be screened for bitterness taste detection thresholds.

Taste-Masked Flucloxacillin Powder Part 1: Optimisation of Fabrication Process Using a Mixture Design Approach

It is extremely challenging to formulate age-appropriate flucloxacillin medicines for young children, because flucloxacillin sodium (FS) has a lingering, highly bitter taste, dissolves quickly in saliva, and requires multiple daily dosing at relatively large doses for treating skin infections. In this paper, we describe a promising taste-masked flucloxacillin ternary microparticle (FTM) formulation comprising FS, Eudragit EPO (EE), and palmitic acid.