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Deep or awake removal of laryngeal mask airway in children at risk of respiratory adverse events undergoing tonsillectomy - a randomised controlled trial

We found no evidence for a difference in the timing of the laryngeal mask airways removal on the incidence of respiratory adverse events

Is forced oscillation technique the next respiratory function test of choice in childhood asthma

While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are unable to perform FOM.

Surgical pleth index: Prediction of postoperative pain in children?

It was the aim of this study to define a clinically appropriate SPI target to predict moderate-severe postoperative pain in children.

A prospective audit of pain profiles following general and urological surgery in children

To determine the duration and severity of acute postoperative pain experienced by children undergoing 8 different general and urological procedures.

The global lung function initiative (GLI) network: Bringing the world’s respiratory reference values together

The Global Lung Function Initiative (GLI) Network has become the largest resource for reference values for routine lung function testing ever assembled.

Premedication with salbutamol prior to surgery does not decrease the risk of perioperative respiratory adverse events in school-aged children

Premedication with salbutamol to children prior to their surgery did not reduce their risk of Perioperative respiratory adverse events

The Impact of Modulator therapy from Early life on lung health trajectories in Cystic Fibrosis (TIME-CF)

Cystic fibrosis is an inherited condition that results in chronic lung disease. In recent years, a new type of medication called CFTR modulators has become available.

Western Australia Paediatric Bronchiectasis Cohort

Bronchiectasis is a chronic lung disease that impairs quality of life and reduces life expectancy.

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups.

Transcriptomic analysis of primary nasal epithelial cells reveals altered interferon signalling in preterm birth survivors at one year of age

Many survivors of preterm birth (<37 weeks gestation) have lifelong respiratory deficits, the drivers of which remain unknown. Influencers of pathophysiological outcomes are often detectable at the gene level and pinpointing these differences can help guide targeted research and interventions. This study provides the first transcriptomic analysis of primary nasal airway epithelial cells in survivors of preterm birth at approximately 1 year of age.