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Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sexdifferential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.
The PELICAN (Prematurity’s Effects on the Lungs in Children and Adults Network) Clinical Research Collaboration was launched by the European Respiratory Society (ERS) in 2020
Cystic fibrosis is an inherited condition that results in chronic lung disease. In recent years, a new type of medication called CFTR modulators has become available.
Bronchiectasis is a chronic lung disease that impairs quality of life and reduces life expectancy.
Functional studies of how early-life interventions shape the airway microbiome remain scarce. Here, we performed metagenomic sequencing of 704 longitudinal nasal swabs from infants with and without cystic fibrosis (CF) to construct and characterize a non-redundant gene atlas of the infant nasal microbiome. We aimed to determine how the nasal microbiome is perturbed by early therapies, as CF is commonly treated with inhaled hypertonic saline to improve mucociliary clearance.
There are differences in tidal breathing parameters during multiple breath washout testing with SF6 gas mixture in infants
The application of the systematic review improved inter-observer agreement but did not affect reported multiple breath washout outcomes
The ANZSRS recommends the adoption of the Global Lung Function Initiative (GLI) 2012 spirometry reference values throughout Australia and New Zealand
The present study investigated whether lung function measured by forced oscillation technique would be impaired in the presence of infection,...
The aim of this study was to use total-population based data on an otherwise healthy population of children to assess the relationship between early...