Skip to content
The Kids Research Institute Australia logo
Donate

No results yet

Search

Showing results for "1"

Research

Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial)

Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. Determining the minimum effective penicillin exposure required to prevent Streptococcus pyogenes infection will accelerate development of new long-acting penicillins for RHD prevention as well as inform opportunities to improve existing regimens. The CHIPS trial will address this knowledge gap by directly testing protection afforded by different steady state plasma concentrations of penicillin in an established model of experimental human S. pyogenes pharyngitis.

Research

International workshop: what is needed to ensure outcome measures for Rett syndrome are fit-for-purpose for clinical trials? June 7, 2023, Nashville, USA

The clinical, research and advocacy communities for Rett syndrome are striving to achieve clinical trial readiness, including having fit-for-purpose clinical outcome assessments. This study aimed to (1) describe psychometric properties of clinical outcome assessment for Rett syndrome and (2) identify what is needed to ensure that fit-for-purpose clinical outcome assessments are available for clinical trials.

News & Events

Supporting Families Project

Proudly funded by a Telethon Trust Research Grant, the Supporting Families project started in 2024 with the aim of co-designing a new clinical pathway for children with early stage type 1 diabetes (T1D).

Research

Responsiveness of the human airway in vitro during deep inspiration and tidal oscillation

In healthy individuals, deep inspiration produces bronchodilation and reduced airway responsiveness, which may be a response of the airway wall to mechanical...

Research

Responsiveness of the human airway in vitro during deep inspiration and tidal oscillation

The aim of this study was to examine the in vitro response of isolated human airways to the dynamic mechanical stretch associated with normal breathing.

Research

Elemental carbon exposure and lung function in schoolchildren from Mexico City

Though exposure to air pollution has a detrimental effect on respiratory health, few studies have examined the association between elemental carbon exposure...

Project Manager, Diabetes Database Development Project

Manage procurement of services and the design, development & implementation of a web-based, integrated diabetes patient management system across WA

CDKL5 Publications

Publications from 2017 dating back to 2004 of CDKL5 researchers.

Research

Risks and obstacles in implementing a public health approach to the wellbeing and protection of children

We have also been engaged with and excited by the attempts to adopt a public health approach to the care and protection of children as described throughout this book