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Research

Developmental Origins of Health and Disease (DOHaD): The importance of life-course and transgenerational approaches

With well-established evidence that early life conditions have a profound influence on lifespan and health-span, new interventional birth cohorts are examining ways to optimise health potential of individuals and communities. These are aimed at going beyond preventing disease, to the conditions that facilitate flourishing from an early age.

Impact: In the Pipeline

On this Research Impact page, we list stories helping to show our exciting in-progress research currently "in the pipeline" towards translation. This is research which shows a real spark of potential to make a significant difference to children and families worldwide.

Research

Maternal prebiotic supplementation during pregnancy and lactation modifies the microbiome and short chain fatty acid profile of both mother and infant

Improving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from <21 weeks' gestation to six months' post-partum, in a double-blinded, randomised placebo-controlled trial.

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Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents

Using prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin...

Research

Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination

Early 7vPCV schedules have limited impact on pneumococcal vaccine type carriage in PNG

Research

Immunogenicity of pneumococcal vaccine schedules in high-risk infants in Papua New Guinea

Deborah Lea-Ann Peter Peter Ruth Lehmann Kirkham Jacoby Richmond Thornton AO, MBBS, MSc PhD BA (Hons) MSc MBBS MRCP(UK) FRACP PhD Honorary Emeritus

Research

Data resource profile: the ORIGINS project databank: a collaborative data resource for investigating the developmental origins of health and disease

The ORIGINS Project (“ORIGINS”) is a longitudinal, population-level birth cohort with data and biosample collections that aim to facilitate research to reduce non-communicable diseases and encourage ‘a healthy start to life’. ORIGINS has gathered millions of datapoints and over 400,000 biosamples over 15 timepoints, antenatally through to five years of age, from mothers, non-birthing partners and the child, across four health and wellness domains.

Research

Cohort Profile: The ORIGINS pregnancy and birth cohort

Desiree Doctor Jackie Susan Lisa Zenobia Silva Davis Prescott Gibson Talati MBBS, FRACP, MPH, PhD BSc (Hons) MBBS BMedSci PhD FRACP BA (Hons), MPsych

Spectrum

Here we recognise donors who have made cumulative gifts of $10,000 and above to contribute to children's health research at The Kids Research Institute Australia.

Research

Prenatal stress and risk of behavioral morbidity from age 2 to 14 years:

The maternal experience of stressful events during pregnancy has been associated with a number of adverse consequences for behavioral development offspring...