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Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic Fibrosis Lung Disease

Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic Fibrosis Lung Disease Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic

CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis

CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis CrossTalk opposing view: mucosal

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis Lung inflammation and infection are common

Air trapping in early cystic fibrosis lung disease—Does CT tell the full story?

Air trapping in early cystic fibrosis lung disease—Does CT tell the full story? Abstract Introduction: Mosaic attenuation on expiratory chest

Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis Early diagnosis and treatment in

Single-breath washout and association with structural lung disease in children with cystic fibrosis

Single-breath washout and association with structural lungdisease in children with cystic fibrosis Abstract Background: In children with cystic

Lung function and exhaled nitric oxide in healthy unsedated African infants

Population-appropriate lung function reference data are essential to accurately identify respiratory disease and measure response to interventions.

The global lung function initiative (GLI) network: Bringing the world’s respiratory reference values together

The Global Lung Function Initiative (GLI) Network has become the largest resource for reference values for routine lung function testing ever assembled.

Epigenome-Wide Association Studies of Chronic Obstructive Pulmonary Disease and Lung Function: A Systematic Review

Chronic obstructive pulmonary disease (COPD) results from gene-environment interactions over the lifetime. These interactions are captured by epigenetic changes, such as DNA methylation.  

SLC6A14 Impacts Cystic Fibrosis Lung Disease Severity via mTOR and Epithelial Repair Modulation

Cystic fibrosis (CF), due to pathogenic variants in CFTR gene, is associated with chronic infection/inflammation responsible for airway epithelium alteration and lung function decline. Modifier genes induce phenotype variability between people with CF (pwCF) carrying the same CFTR variants. Among these, the gene encoding for the amino acid transporter SLC6A14 has been associated with lung disease severity and age of primary airway infection by the bacteria Pseudomonas aeruginosa.