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By participating in ORIGINS, you are contributing to one of the largest and most comprehensive birth cohort studies in Australia.

ORIGINS Project shines light on Early Childhood Development

A collaboration between The Kids Research Institute Australia and Joondalup Health Campus is poised to be a game-changer for early childhood development.

ORIGINS family finds comfort and community

A Quinns Rocks family who became the 1000th family to sign up for the ORIGINS Project is excited to be contributing to such ground-breaking research.

ORIGINS is pleased to announce the 2024 recipient of its inaugural PhD Student Award

Miss Braddon will be awarded with $15,000 to go towards her research project, DreamStart

Now We Are Five - ORIGINS celebrates milestone

ORIGINS is celebrating its first five-year-old 'graduates'.

Available Data & Biological Samples

ORIGINS is collecting data from multiple sources from the mother, infant and partner at multiple timepoints from gestation through to five years of age.

Biobank funding supports valuable research resources

Four The Kids Research Institute Australia-based biobanks which underpin a range of cancer, respiratory and early life research have received more than $450,000 in funding.

Benefits for ORIGINS families

ORIGINS is an interventional cohort study, meaning participants receive timely feedback and an action plan to address any potential abnormalities.

Benefits for ORIGINS Families

ORIGINS is an interventional cohort study, meaning participants receive timely feedback and an action plan to address any potential abnormalities.

PKC activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity

A significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells, associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. However, the importance of PKCζ signalling in regulating their differentiation from a Th2 to a Th1 cytokine phenotype propensity remains undefined.