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The Heavy Metal Tooth Fairy Project

This Australian-first study will simultaneously identify childhood exposure to heavy metals in regional and remote communities and provide these communities with training in drinking water quality, STEM and dental hygiene.

The PLANET Project

Plastics in Pregnancy (Phase One)

TUMS

Supporting healthy tummies in bubs

Examining Sub-Fertility In a Prospective Birth Cohort

This research aims to examine subfertility in a population pregnancy cohort, analysing the underlying differences between sub fertile couples who conceive naturally, sub fertile couples who conceive using ART or non-IVF, and fertile couples.

Sub-project Summary

An outline of ORIGINS' active and completed sub-projects.

Cessation of Courier Service

ORIGINS is no longer offering courier services or home collection of samples.

Maternal and Child Mental Health and Wellbeing

Examining the pathways of perinatal maternal mental health that influence child mental health outcomes.

PKC activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity

A significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells, associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. However, the importance of PKCζ signalling in regulating their differentiation from a Th2 to a Th1 cytokine phenotype propensity remains undefined.

Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents

Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described.

The feasibility of a digital health approach to facilitate remote dental screening among preschool children during COVID-19 and social restrictions

Tele-dentistry can be useful to facilitate screening of children, especially those living in rural and remote communities, and during the COVID-19 pandemic. This study evaluated the feasibility of tele-dental screening for the identification of early childhood caries (ECC) in preschoolers using an app operated by their parents with remote review by oral-health therapists.