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Multiple-breath washout as a lung function test in cystic fibrosis: A cystic fibrosis foundation workshop reportRecent technological advances in equipment design have produced gains in popularity for this test among cystic fibrosis (CF) researchers and clinicians...
Research
Preterm lung disease: not just for neonatologistsImprovements in neonatal critical care have resulted in more people than ever reaching adulthood after being born prematurely. At the same time, it is becoming clearer that preterm birth can increase the risk of respiratory disease throughout a person’s lifetime. Awareness that a patient was born preterm can enable early specialist assessment and intervention when there is any concern about lung health.
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Factors influencing participation in home, school, and community settings by children and adolescents with neuromuscular disorders: A qualitative descriptive studyThis study explored how children and adolescents with a neuromuscular disorder (NMD) and their parents experienced barriers and enablers to the child's participation.
The Children's Lung Health Team investigates lung growth and development through infancy, childhood, adolescence and early adulthood, in health and in chronic lung disease, and the impact of preterm birth on lung health outcomes.
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Using lung function measurements to greater advantage in patients with lung disease: Which test and when?This paper is an introduction to a series of articles about improved measurement of lung function in patients with chronic lung disease.
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Novel drug targets for asthma and COPD: Lessons learned from in vitro and in vivo modelsThis paper is a review of potential novel therapeutic targets or tools for the treatment of asthma and COPD.
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Early surveillance of infants and preschool children with cystic fibrosisSensitive and non-invasive surveillance tools are needed for the clinical management of infants and preschool children with cystic fibrosis (CF). The lung clearance index from the multiple breath washout and functional and morphological outcomes from magnetic resonance imaging provide promising alternatives to current gold standard techniques. Early detection and treatment of lung disease during this important period offers the opportunity to improve the quality of life for individuals with CF.
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Oscillometry and spirometry are not interchangeable when assessing the bronchodilator response in children and young adults born pretermThe European Respiratory Society Oscillometry Taskforce identified that clinical correlates of bronchodilator responses are needed to advance oscillometry in clinical practice. The understanding of bronchodilator-induced oscillometry changes in preterm lung disease is poor. Here we describe a comparison of bronchodilator assessments performed using oscillometry and spirometry in a population born very preterm and explore the relationship between bronchodilator-induced changes in respiratory function and clinical outcomes.
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Simultaneous multiple breath washout and oxygen-enhanced magnetic resonance imaging in healthy adultsLung function testing and lung imaging are commonly used techniques to monitor respiratory diseases, such as cystic fibrosis (CF). The nitrogen (N2) multiple-breath washout technique (MBW) has been shown to detect ventilation inhomogeneity in CF, but the underlying pathophysiological processes that are altered are often unclear.
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Arsenic and respiratory diseaseArsenic is the only environmental toxin that has been linked to both malignant and nonmalignant respiratory disease following ingestion, rather than inhalation, making arsenic a unique toxicant to the respiratory system. Chronic exposure to arsenic has been associated with the development of respiratory symptoms, impaired lung function, and chronic lung disease.