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Research

Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma

Supratentorial RELA fusion (ST-RELA) ependymomas (EPNs) are resistant tumors without an approved chemotherapeutic treatment. Unfortunately, the molecular mechanisms that lead to chemoresistance traits of ST-RELA remain elusive. The aim of this study was to assess RELA fusion-dependent signaling modules, specifically the role of the Hedgehog (Hh) pathway as a novel targetable vulnerability in ST-RELA.

Research

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues

Poo and You!

Discover resources and science activities for kids for the topic 'Poo and You!'.

Power of Our Lungs

Discover resources and science activities for kids for the topic 'Power of Our Lungs'.

Rhinovirus infection drives complex host airway molecular responses in children with cystic fibrosis

Rhinovirus infection drives complex host airway molecular responses in children with cystic fibrosis TEarly-life viral infections are responsible for

News & Events

Time for WA’s ‘wait awhiles’ to get vaccinated

Researchers leading a study into COVID-19 vaccine hesitancy say a sub-group of people they’ve dubbed the ‘wait awhiles’

Research

Personalized transcriptomics reveals heterogeneous immunophenotypes in children with viral bronchiolitis

Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants

Research

Outcomes of an international workshop on preconception expanded carrier screening: Some considerations for governments

Consideration of expanded carrier screening has become an emerging issue for governments.

Research

Respiratory syncytial virus is present in the neonatal intensive care unit

The results suggest that though the risk for RSV in the NICU remains low, personnel clothing are contaminated with RSV-RNA and may have a role in transmission

Research

Exercise to prevent late-onset hypoglycemia in individuals with type1 diabetes

A 10-s sprint performed after 30 min of moderate-intensity exercise does not affect the amount of carbohydrate required to maintain euglycemia postexercise...