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Influence of secular trends and sample size on reference equations for lung function tests

The aim of our study was to determine the contribution of secular trends and sample size to lung function reference equations, and establish the number...

Variants associated with HHIP expression have sex-differential effects on lung function

Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.

Early Years Systems Evidence

The Early Years Systems Evidence (EYSE) team specialises in working in partnership with governments and service providers, with a distinct focus on improving the life chances of children in Australia.

Cystic Fibrosis Early Surveillance Program

Researchers are able to track the progress of lung disease through a comprehensive longitudinal set of biological samples, images and data archives.

Research priorities for preterm lung health research across the lifespan: a community priority setting partnership

It is essential to embed patient and public perspectives into every stage of the research journey, including setting the future research agenda. The substantial gaps in our understanding of prematurity-associated lung disease presented a timely opportunity to determine the community's research priorities.

Lung function trajectories throughout childhood in survivors of very preterm birth: a longitudinal cohort study

Lung function trajectories are impaired in survivors of very preterm birth

Impact of lung disease on respiratory impedance in young children with cystic fibrosis

The present study investigated whether lung function measured by forced oscillation technique would be impaired in the presence of infection,...

Association between diesel engine exhaust exposure and lung function in Australian gold miners

Diesel engine exhaust exposures were higher in underground miners and had a negative association with their lung function over a single 12-h shift

The potential of antisense oligonucleotide therapies for inherited childhood lung diseases

Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design.

Exhaled breath temperature in healthy children is influenced by room temperature and lung volume

Exhaled breath temperature (EBT) has been proposed for the non-invasive assessment of airway inflammation