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T regulatory cells in childhood asthmaAsthma is a chronic disease of the airways, most commonly driven by immuno-inflammatory responses to ubiquitous airborne antigens.
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Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell toleranceConcerns about the risk of inducing immune deviation-associated "neonatal tolerance" as described in mice have restricted the widespread adoption...
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Does genetic regulation of IgE begin in utero?Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allerg
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Modulation of the postnatal maturation of immune function during early life: studies on the effects of natural infections and exposure to the bacterial-derived immunoenhancer OM85Severe winter lower respiratory infections in early life are known to be major risk factors for subsequent development of asthma, and it is also known that the high susceptibility to these infections in infants is due to the functional immaturity of their immune systems.
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Immune function during early adolescence positively predicts adult facial sexual dimorphism in both men and womenOur results support a fundamental assumption that facial sexual dimorphism is an indicator of immune function during the development of facial sexual dimorphism
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Protection against maternal infection-associated fetal growth restriction: Proof-of-concept with a microbial-derived immunomodulatorThis study suggests that broad-spectrum protection-of-pregnancy against infection-associated inflammatory stress represents an achievable therapeutic goal
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Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.Recurrent severe asthma exacerbations are associated with decreased lung growth or accelerated loss of long function and add substantially to cost and morbidity
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The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma DevelopmentLung inflammation resulting from ARIs during infancy is linked to asthma development.
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Identification and characterization of a dendritic cell precursor in parenchymal lung tissueThis is the first study to describe a pulmonary precursor cell for dendritic cells in lung tissue
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Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marksWe identified new asthma loci, found new associations at loci implicated in the comorbidity of asthma plus hay fever and confirmed nine known loci.