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Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marksWe identified new asthma loci, found new associations at loci implicated in the comorbidity of asthma plus hay fever and confirmed nine known loci.
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Protection against maternal infection-associated fetal growth restriction: Proof-of-concept with a microbial-derived immunomodulatorThis study suggests that broad-spectrum protection-of-pregnancy against infection-associated inflammatory stress represents an achievable therapeutic goal
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The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma DevelopmentLung inflammation resulting from ARIs during infancy is linked to asthma development.
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Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.Recurrent severe asthma exacerbations are associated with decreased lung growth or accelerated loss of long function and add substantially to cost and morbidity
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Identification and characterization of a dendritic cell precursor in parenchymal lung tissueThis is the first study to describe a pulmonary precursor cell for dendritic cells in lung tissue
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Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of riskA hallmark of atopic asthma is development of chronic airways hyper-responsiveness (AHR) that persists in the face of ongoing exposure to perennial...
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Effect of early carriage of streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancyThe aim of this study was to examine the relationship between nasopharyngeal pneumococcal colonization in early life and the development of T cell responses.