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Reducing exacerbations in children and adults with primary ciliary dyskinesia using erdosteine and/or azithromycin therapy (REPEAT trial): study protocol for a multicentre, double-blind, double-dummy, 2×2 partial factorial, randomised controlled trialPrimary ciliary dyskinesia (PCD) is a rare, progressive, inherited ciliopathic disorder, which is incurable and frequently complicated by the development of bronchiectasis. There are few randomised controlled trials (RCTs) involving children and adults with PCD and thus evidence of efficacy for interventions are usually extrapolated from people with cystic fibrosis.
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How might we increase physical activity through dog walking?: A comprehensive review of dog walking correlatesCurrent evidence suggests that dog walking may be most effectively encouraged through targeting the dog-owner relationship and by providing dog-supportive...
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Gateways to the FANTOM5 promoter level mammalian expression atlasThe FANTOM5 project investigates transcription initiation activities in more than 1,000 human and mouse primary cells, cell lines and tissues using CAGE.
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No dose-dependent increase in fracture risk after long-term exposure to high doses of retinol or beta-caroteneThis intervention study found no increase in fracture risk among 2,322 adults who took a controlled, high-dose retinol supplement for as long as 16 years.
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Prenatal maternal stress associated with ADHD and autistic traits in early childhoodResearch suggests that offspring of mothers who experience high levels of stress during pregnancy are more likely to have problems in neurobehavioral...
Get some key information about some of the most popular questions that people are asking about the Discovery Centre.
One of the many reasons for setting up the International CDKL5 Disorder Database was to learn more about this condition.
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Play Active physical activity policy intervention and implementation support in early childhood education and care: results from a pragmatic cluster randomised trialPolicy interventions to increase physical activity in early childhood education and care (ECEC) services are effective in increasing physical activity among young children. However, a large proportion of ECEC services do not have nor implement a physical activity policy.
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Circulating Soluble Factors and T-Cell Subsets as Immunological Predictors of Therapy Response in Human Cutaneous LeishmaniasisHuman cutaneous leishmaniasis, a neglected tropical disease caused by Leishmania braziliensis, presents treatment challenges due to varying therapeutic responses. Current therapies often encounter limited efficacy and treatment failure, demanding a deeper understanding of immunopathogenesis and predictive markers.
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Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockadeAntibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4, programmed cell death protein/ligand 1 are approved for treatment of multiple cancer types.