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Research

Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation

The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address this fundamental question we used CRISPR editing to knockout the seven-membered phenylalanine tRNA gene family in mice, both individually and combinatorially.

Research

Survival and mortality in cerebral palsy: Observations to the sixth decade from a data linkage study of a total population register and National Death Index

Since 1990 mortality for those with severe cerebral palsy in Western Australia has tended to shift from childhood to early adulthood

Research

A Diagnosis for All Rare Genetic Diseases: The Horizon and the Next Frontiers

There is a critical need for the field to develop and implement strategies to understand the mechanisms underlying all rare diseases and translate these to clinical care

Research

Early vaccination protects against childhood leukemia: A systematic review and meta-analysis

Growing evidence supports a role for infection in the etiology of ALL and the involvement of immune systems suggests that vaccination may also play a role.

News & Events

Community Involvement critical to research

Understanding the experiences of those living with a chronic condition such as type 1 diabetes (T1D) has been the topic of conversation throughout the medical research community over the last decade or so.

News & Events

Christmas nutrition tips

We asked our nutrition research lead and Accredited Practising Dietitian, Dr Amelia Harray, for her advice on how to enjoy food and stay on track with managing type 1 diabetes over Christmas.

News & Events

Diabetes Australia app

Diabetes Australia have released an app to make living with or caring for someone with diabetes a little easier.

Science at Home: Build a lung model!

Have you ever wondered how your lungs work? Researchers from our Children’s Lung Health Team show you how to make a simple lung model by using common household items.

Research

A comparison of videolaryngoscopy using standard blades or non-standard blades in children in the Paediatric Difficult Intubation Registry

The design of a videolaryngoscope blade may affect its efficacy. We classified videolaryngoscope blades as standard and non-standard shapes to compare their efficacy performing tracheal intubation in children enrolled in the Paediatric Difficult Intubation Registry.

Research

A comparative study of extracellular vesicle-associated and cell-free DNA and RNA for HPV detection in oropharyngeal squamous cell carcinoma

Our study demonstrates that although HPV-DNA/RNA can be detected in EV associated DNA/RNA, cf-DNA/RNA is the more sensitive liquid biopsy medium