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Research
A study to prolong breastfeeding duration: Design and rationale of the Parent Infant Feeding Initiative (PIFI) randomised controlled trial.This study aimed to measure the effectiveness of three interventions designed to increase the duration of breastfeeding among new parents in urban areas.
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Validation and Application of a Dried Blood Spot Amoxicillin AssayDried blood spot (DBS) antibiotic assays can facilitate pharmacokinetic (PK) investigations in situations where venous blood sampling is logistically and/or ethically challenging. The aim of this study was to establish, validate and demonstrate the application of a DBS amoxicillin assay for PK studies in vulnerable populations.
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Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation early developmentThe predominant occurrence of extragonadal teratomas/teratocarcinomas in human neonates suggests that pluripotent cells are tumour-forming even during...
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Caregiver Perspective of Benefits and Side Effects of Anti-Seizure Medications in CDKL5 Deficiency Disorder from an International DatabaseCDKL5 deficiency disorder presents as a challenging condition with early-onset refractory seizures, severe developmental delays, and a range of other neurological symptoms. Our study aimed to explore the benefits and side effects of anti-seizure medications in managing seizures among individuals with CDKL5 deficiency disorder, drawing on data from the International CDKL5 Disorder Database.
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Using theory to improve low back pain care in Australian Aboriginal primary care: A mixed method single cohort pilot studyLow back pain (LBP) care is frequently discordant with research evidence.
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Pathways of Socioeconomic Disadvantage and Peer Bullying in Children and Youth: A Scoping ReviewGrowing up in socioeconomic disadvantage increases risk of peer bullying at school. Both socioeconomic status and involvement in bullying are predictive of a range of adverse developmental outcomes. However, neither (a) the mechanisms whereby disadvantage increases bullying risk nor (b) the developmental outcomes for which bullying may mediate disadvantage are clear.
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Timing of excision after a non-severe burn has a significant impact on the subsequent immune response in a murine modelEarly excision of the wound, during the phase of immune down-regulation initiated by the burn, maintains an innate and adaptive immune cell response
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Intervention effect of targeted workplace closures may be approximated by single-layered networks in an individual-based model of COVID-19 controlIndividual-based models of infectious disease dynamics commonly use network structures to represent human interactions. Network structures can vary in complexity, from single-layered with homogeneous mixing to multi-layered with clustering and layer-specific contact weights. Here we assessed policy-relevant consequences of network choice by simulating different network structures within an established individual-based model of SARS-CoV-2 dynamics.
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Measuring exposure to solar ultraviolet radiation using a dosimetric technique: Understanding participant compliance issuesWe investigated the types and determinants of noncompliance associated with a protocol for use of polysulphone UVR dosimeters.
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Comparing Skin and Serum Testing to Direct Challenge Outcomes in Children With beta-Lactam AllergiesThere is a scarcity of prospective studies investigating the relative roles of skin prick and intradermal testing, serum specific IgE, and extended oral challenges in diagnosing children with reported β-lactam allergies.
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Parental experiences of early pulmonary surveillance for children with cystic fibrosis: A research proposal for improved family psychosocial outcomesThe proposed study intends to explore parental experiences, including coping, related to their child's involvement in the early surveillance program.
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Impact of early childhood infection on child development and school performance: a population-based studyChildhood infection might be associated with adverse child development and neurocognitive outcomes, but the results have been inconsistent.
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Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort studyIncreased prenatal testosterone exposure has been hypothesized as a mechanism underlying autism spectrum disorders (ASD).
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Correction to: Can flash glucose monitoring improve glucose management for Aboriginal and Torres Strait Islander peoples with type 2 diabetes? A protocol for a randomised controlled trial (Trials, (2024), 25, 1, (493), 10.1186/s13063-024-08267-7)Alex Brown BMed, MPH, PhD, FRACP (hon.), FCSANZ, FAAHMS Professor of Indigenous Genomics +61421278314 alex.brown@anu.edu.au Professor of Indigenous
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House dust allergy and immunotherapyHDM allergy is associated with asthma, allergic rhinitis and atopic dermatitis.
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Edaravone for the Treatment of Motor Neurone Disease: A Critical Review of Approved and Alternative Formulations against a Proposed Quality Target Product ProfileEdaravone is one of two main drugs for treating motor neurone disease (MND). This review proposes a specific quality target product profile (QTPP) for edaravone following an appraisal of the issues accounting for the poor clinical uptake of the approved IV and oral liquid edaravone formulations. This is followed by a review of the alternative oral formulations of edaravone described in the published patent and journal literature against the QTPP.
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Epidemiology of hypoglycaemia in childhood-onset diabetes in Western AustraliaInvestigating the demographic, lifestyle and diabetes management factors associated with the incidence of severe hypoglycemia
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Effects of a live versus heat-inactivated probiotic Bifidobacterium spp in preterm infants: a randomised clinical trialHeat-inactivated probiotics (HPs) may provide an effective alternative to live probiotics by avoiding their risks (eg, probiotic sepsis) while retaining the benefits. We assessed the safety and efficacy of a HP in very preterm (VP: gestation <32 weeks) infants.
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Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across speciesAlcohol consumption in pregnancy can affect genome regulation in the developing offspring but results have been contradictory. We employed a physiologically relevant murine model of short-term moderate prenatal alcohol exposure resembling common patterns of alcohol consumption in pregnancy in humans.
Imagine living with a condition that requires you to make approximately 180 health- related decisions every day for the rest of your life.