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Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described.
Complementary feeding induces dramatic ecological shifts in the infant gut microbiota toward more diverse compositions and functional metabolic capacities, with potential implications for immune and metabolic health. The aim of this study was to examine whether the age at which solid foods are introduced differentially affects the microbiota in predominantly breastfed infants compared with predominantly formula-fed infants.
Tele-dentistry can be useful to facilitate screening of children, especially those living in rural and remote communities, and during the COVID-19 pandemic. This study evaluated the feasibility of tele-dental screening for the identification of early childhood caries (ECC) in preschoolers using an app operated by their parents with remote review by oral-health therapists.
The ORIGINS Biobank is collecting biological samples from participant families at 10 timepoints between the time of pregnancy and the child turning five years of age.
ORIGINS is collecting physiological, biological and clinical data from the mother, partner/father and child at numerous points to track development and change.
View the ORIGINS Data Catalogue hosted by Power BI
Accessing the ORIGINS cohort, database or biological samples involves a process of review and approval.
Information about the sub-project implementation process at ORIGINS
A list of organisations that currently collaborate with ORIGINS.
ORIGINS is fortunate to have a small passionate and dedicated group of longstanding volunteers.