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Research
Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancerThe Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations.
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Type 2 diabetes in children and adolescents across Australia and New Zealand: A 6‐year audit from The Australasian Diabetes Data Network (ADDN)To assess the clinical and demographic characteristics of children and adolescents across Australia and New Zealand (NZ) with type 2 diabetes.
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‘Can you sleep tonight knowing that child is going to be safe?’: Australian community organisation risk work in child protection practiceRisk averse practice has dominated the child protection field for decades, with high-profile child deaths, ever-tightening surveillance, and regulation of families. In this context, the practice of social work as ‘risk work’ including the use of risk assessment tools has been subject to substantial scholarly investigation. Less attention has been paid to the community organisations that play a central role in supporting child protection-involved parents. Based on interviews with Australian community workers, we examine their negotiation of the parent support/parent risk dichotomy.
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Continuous Glucose Monitoring Adherence: Lessons from a Clinical Trial to Predict Outpatient BehaviorContinuous glucose monitoring adherence and patterns of use are individualized
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Schizophrenia Spectrum Disorders and Autism Spectrum DisorderWe examine the level of comorbidity found between Autism spectrum disorder and Schizophrenia spectrum disorders at a clinical and trait level
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Time series analysis of RSV and bronchiolitis seasonality in temperate and tropical Western AustraliaBronchiolitis hospitalisations are a reasonable proxy for the timing of RSV detections, but may not fully capture the magnitude of RSV epidemics
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A novel clinical prediction model for prognosis in malignant pleural mesothelioma using decision tree analysisA simple, clinically relevant model to reliably discriminate patients at high and lower risk of death in patients with malignant pleural mesothelioma
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Temporal trends in cerebral palsy by impairment severity and birth gestationRates of cerebral palsy in Victoria decreased between the mid-1990s and 2009 for neonatal survivors of all birth gestations
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Conceptualizing a quality of life framework for girls with Rett syndrome using qualitative methodsExisting quality of life scales for children in the general population or with other disabilities did not capture the QOL of children with Rett syndrome
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N-3 fatty acid supplementation and leukocyte telomere length in patients with chronic kidney diseaseReducing oxidative stress, could modify telomere erosion during cell replication, and cardiovascular disease risk in patients with chronic kidney disease