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In asthma, a significant portion of the interaction between genetics and environment occurs through microbiota. The proposed mechanisms behind this interaction are complex and at times contradictory. This review covers recent developments in our understanding of this interaction: the "microbial hypothesis" and the "farm effect"; the role of endotoxin and genetic variation in pattern recognition systems; the interaction with allergen exposure; the additional involvement of host gut and airway microbiota; the role of viral respiratory infections in interaction with the 17q21 and CDHR3 genetic loci; and the importance of in utero and early-life timing of exposures.
As the rise in prevalence of allergic diseases worldwide corresponds in time with increasing infant vaccination, it has been hypothesized that childhood vaccination may increase the risk of allergic disease. We aimed to synthesize the literature on the association between childhood vaccination and allergy.
These findings suggest that genetic variants at the VDR locus may play a role in acute wheeze/asthma severity in children
We demonstrate that NOTCH3 is a regulator of MUC5AC production
These findings suggest the utility of specific FOT outcomes is dependent on the respiratory disease being assessed
Type 1 and 3 interferon response capacity appears strongly developmentally constrained at birth
Here, we review the basic concepts in bioinformatics and genomic data analysis and illustrate the application of these tools to further our understanding of lung diseases
To complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children
Data indicate a role for Interferonβ in linking viral infection and allergy
The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood