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Group A Streptococcus (GAS) is a major human pathogen responsible for superficial infections through to life-threatening invasive disease and the autoimmune sequelae acute rheumatic fever (ARF). Despite a significant global economic and health burden, there is no licensed vaccine available to prevent GAS disease. Several pre-clinical vaccines that target conserved GAS antigens are in development.

We observed an association between Type III DNA methyltransferase presence and Otitis Media-associated middle ear isolates

These data provide evidence that otitis-prone children do not have impaired functional cell mediated immunity

We have previously demonstrated that mice exposed to geogenic dust PM10 experienced an exacerbation of inflammatory responses to influenza A virus.

We aim to determine the contribute of bacteria and virus to childhood CAP to inform further development of effective strategies.

Vaccination trials in high endemicity areas are needed to provide evidence and guidance on idea strategies to protect children in these areas against infections

This Clinical Puzzle article describes our current knowledge of chronic otitis media and the existing research models for this condition

Chronic inflammation may expand sub-populations of T cells expressing CTLA-4 in COPD patients and therefore impair T-cell function

We have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo

The most urgent areas appear to be to continue monitoring the emergence of novel otopathogens, and the need to develop prevention and preventative therapies