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Research
Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorderASD's are complex, pervasive and heterogeneous neurodevelopmental conditions with varying conditions, trajectories, significant male bias and unknown etiology.
Research
Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial CellsApically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces.
Research
Assessment of p.Phe508del-CFTR functional restoration in pediatric primary cystic fibrosis airway epithelial cellsThis study assessed an alternative approach, using a small scale halide assay that can be adapted for a personalized high throughput setting to analyze CFTR function of pAEC.
Research
FDA Patient-Focused Drug Development Guidances: Considerations for Trial Readiness in Rare Developmental and Epileptic EncephalopathiesDevelopmental and epileptic encephalopathies (DEE) are rare, often monogenic neurodevelopmental conditions. Most affected individuals have refractory seizures. All have multiple severe impairments which can be as life-limiting as or more limiting than the seizures themselves. Mechanism- and gene-targeted therapies for these individually rare, genetic conditions hold hope for treatment, amelioration of disease expression, and even cure.
Research
The pervasive effects of timing of parental mental health disorders on adolescent deliberate self-harm riskThis study shows that timing is important for understanding intergenerational transmission of deliberate self-harm risk
Research
Using linked data to investigate developmental vulnerabilities in children of convicted parentsAlthough children of convicted parents experience a higher incidence of sociodemographic risk, their parents' criminal activity constitutes an independent risk factor for their development
Research
Predictors of vitamin D-containing supplement use in the Australian population and associations between dose and serum 25-hydroxyvitamin D concentrationsThe prevalence of vitamin D-containing supplement use was generally low in the Australian population, particularly for single vitamin D supplements
News & Events
Insulin pumps give better glycaemia outcomes for children than MDIChildren with type 1 diabetes using an insulin pump have better glycaemic control than to those using multiple daily injections (MDI) of insulin, a new Children's Diabetes Centre study has found.
ORIGINS has several sub-projects exploring allergy development within the cohort, with a focus on nutritional strategies for allergy prevention.
Find out about the research outputs for the Development Pathways Project, and see the published research outcomes.