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Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allerg
The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined.
The epithelium is integral to the protection of many different biological systems and for the maintenance of biochemical homeostasis. Emerging evidence suggests that particular children have epithelial vulnerabilities leading to dysregulated barrier function and integrity, that resultantly contributes to disease pathogenesis.
Bacterial colonisation of the airways is associated with increased risk of childhood asthma
Digit ratio (2D:4D) is widely used as a marker of prenatal androgen exposure
There is a growing understanding that chronic respiratory diseases in adults have their origins in early life
Epidemiologic associations between viral lower respiratory infections (LRIs) and asthma in later childhood are well known
Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity.
Atopy and asthma are commonly initiated during early life, and there is increasing interest in the development of preventive treatments for at-risk children.
This study investigates the impact of measuring adherence and providing feedback on medication usage by children with unstable asthma.