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FDA Patient-Focused Drug Development Guidances: Considerations for Trial Readiness in Rare Developmental and Epileptic EncephalopathiesDevelopmental and epileptic encephalopathies (DEE) are rare, often monogenic neurodevelopmental conditions. Most affected individuals have refractory seizures. All have multiple severe impairments which can be as life-limiting as or more limiting than the seizures themselves. Mechanism- and gene-targeted therapies for these individually rare, genetic conditions hold hope for treatment, amelioration of disease expression, and even cure.
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Socio-demographic correlates of unhealthy lifestyle in Ethiopia: a secondary analysis of a national surveyMultiple lifestyle risk factors exhibit a stronger association with non-communicable diseases (NCDs) compared to a single factor, emphasizing the necessity of considering them collectively. By integrating these major lifestyle risk factors, we can identify individuals with an overall unhealthy lifestyle, which facilitates the provision of targeted interventions for those at significant risk of NCDs. The aim of this study was to evaluate the socio-demographic correlates of unhealthy lifestyles among adolescents and adults in Ethiopia.
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Surveillance of antenatal influenza vaccination: Validity of current systems and recommendations for improvementAlthough influenza vaccination is recommended during pregnancy as standard of care, limited surveillance data are available for monitoring uptake.
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Messages that increase women's intentions to abstain from alcohol during pregnancyPublic awareness-raising campaigns targeting alcohol use during pregnancy are an important part of preventing prenatal alcohol exposure and FASD.
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Recommendations from a consensus development workshop on the diagnosis of fetal alcohol spectrum disorders in Australia.Fetal alcohol spectrum disorders (FASD) are underdiagnosed in Australia, and health professionals have endorsed the need for national guidelines for diagnosis.
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Common variation contributes to the genetic architecture of social communication traitsSocial communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development.
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The conductive environment enhances gross motor function of girls with Rett syndrome. A pilot studyThis study assessed the functional skills of three girls with RTT aged 35 years before and during participation in a CE programme.
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Collaborating with consumer and community representatives in health and medical research in Australia:The objective of this tudy was to collaborate with consumer and community representatives in the Alcohol and Pregnancy Project from 2006-2008
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Influence of secular trends and sample size on reference equations for lung function testsThe aim of our study was to determine the contribution of secular trends and sample size to lung function reference equations, and establish the number...
This project aims to investigate the impact of a non-severe burn injury on children's health for life.