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News & Events
Hospital staff effective at reporting child abuseA new study from Perth's The Kids for Child Health Research has found that most cases of child abuse or neglect that are identified in hospital are...
Research
Healthway Kimberly CompassionIn this project, we aim to understand how mindfulness, compassion, and related constructs are experienced by Aboriginal people in the Kimberley region of Western Australia.
Research
Mitochondrial Gene TherapyAleksandra Filipovska BSc PhD Louis Landau Chair in Child Health Research; NHMRC Leadership Fellow; Deputy Director, ARC Centre of Excellence for
Research
Preparing for prevention: Assessing the community awareness of RSV and other childhood infectionsRespiratory Syncytial Virus (RSV) is one of the most common reasons babies are admitted to hospital – with Aboriginal and preterm infants at greatest risk.
The year 2020 has been marked by possibly the greatest health challenge to face modern society. The emergence of COVID-19 as a novel human pathogen
Research
Genetic and functional evidence implicating DLL1 as the gene that influences susceptibilityVisceral leishmaniasis (VL) is caused by Leishmania donovani and Leishmania infantum chagasi. Genome-wide linkage studies from Sudan and Brazil identified...
News & Events
Researchers uncover the hidden wonder of cellsResearchers from The Kids Research Institute Australia and The University of Western Australia have developed a new technique to see inside cells with unprecedented detail, revealing a complicated web of interactions that provides new insights into how cells stay healthy.
News & Events
Serve and return interactionsIn this blog, Speech Pathology Clinical Lead Aria May discusses serve and return interactions to promote connection and communication with your child.
Research
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastomaMedulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.