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Research
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastomaMedulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.
News & Events
Developing a pencil graspIn this blog, Senior Occupational Therapist Gayle Hillen explores the steps to developing a functional pencil grasp.
News & Events
Looking at autism through a social modelIn​ this blog, Speech Pathologist Linda Arabi discusses the social model and how it influences the supports we provide to autistic children and their families.
News & Events
Assessing COVID-19 Across Western Australian SchoolsWestern Australia has been highly successful at containing community spread of COVID-19 to date.
News & Events
Sun safe: balancing the risks and benefitsThe D-Light program, set up in 2014, aims to shed light on the amount of sun exposure that will promote good health in children and adolescents.
News & Events
New study shows no consistent decrease in child maltreatmentA new study of child maltreatment over the last 20 years in developed countries has found no consistent decrease in rates despite a raft of policy initiatives.
Research
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis...
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News & Events
Triage phone serviceA reminder we have updated our Phone Triage System and provided a triage helpful tips sheet for all families to access.