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ORIGINS Timepoints & Requirements

Learn about our timepoints for online questionnaires and Kids Check Appointments.

Research

Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma

Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.

Research

Trans Pathways

Trans Pathways is the largest study ever in Australia of gender diverse young people and their mental health and care pathways.

Research

The effect of oral insulin on subcutaneous insulin requirements and glycaemia in T1DM

Liz Tim Davis Jones MBBS FRACP PhD MBBS DCH FRACP MD Co-director of Children’s Diabetes Centre Co-head, Diabetes and Obesity Research Co-director of

Research

The effectiveness of education and lived experience resources in reducing stigma towards young people at-risk of psychosis

This study aimed to evaluate and compare the effectiveness of two brief written anti-stigma resources.

News & Events

Funding to support research into the impact of standing wheelchairs

The Kids researchers are investigating the physical and psychological impacts of powered standing wheelchairs for boys suffering from Duchenne

News & Events

New test proves effective in more cancers

Avantogen Limited (ACU:ASX) today announced that cancer researchers at Perth's The Kids for Child Health Research (TICHR) and Avantogen Limited

Case Study: NEC

NEC Australia has joined forces with The Kids Research Institute Australia to ensure a state-of-the-art ICT system is in place at the new Perth Children’s Hospital.

News & Events

Impact through communication

Speech Pathology Week 2025 at CliniKids.

Research

Vitamin D and Sunlight

In a sunny country such as Australia, it’s important to identify how to achieve the right amount of sun exposure for good health. We need to be able to harness the benefits of vitamin D and sunlight while remaining protected from the proven dangers of too much UV radiation.