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Showing results for "early lung health"
Research
Influence of secular trends and sample size on reference equations for lung function testsThe aim of our study was to determine the contribution of secular trends and sample size to lung function reference equations, and establish the number...
News & Events
Meet the Finalists: Illuminate PitchFest 2024Illuminate PitchFest is back! We are excited to introduce you to 10 trailblazing researchers who will be taking to the stage this February to pitch their bold and bright ideas.
News & Events
Thumbs up from first preterm study participant to use new lung function testing equipmentNatasha, who is a participant in the West Australian Lung Health in Prematurity (WALHIP) study, this week became the first person to receive a lung health assessment using new state-of-the-art lung function testing equipment at Perth Children’s Hospital.
Research
PELICAN: Prematurity’s Effects on the Lungs in Children and Adults NetworkThe PELICAN (Prematurity’s Effects on the Lungs in Children and Adults Network) Clinical Research Collaboration was launched by the European Respiratory Society (ERS) in 2020
Our team aims to optimise lung health early in life to ensure the best possible health outcomes later in life.
Research
Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infantsInflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity.
Research
Lung inflammation and simulated airway resistance in infants with cystic fibrosisCystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance.
Research
Long-term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and elicits hyperactive behaviours in young adulthoodAtmospheric carbon dioxide (CO2) levels are currently at 418 parts per million (ppm), and by 2100 may exceed 900 ppm. The biological effects of lifetime exposure to CO2 at these levels is unknown. Previously we have shown that mouse lung function is altered by long-term exposure to 890 ppm CO2. Here, we assess the broader systemic physiological responses to this exposure.
Research
Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airway resistance, decreased diaphragm strength, and no change in alveolar structureMucopolysaccharidosis type IIIA (MPS IIIA) is characterized by neurological and skeletal pathologies caused by reduced activity of the lysosomal hydrolase, sulfamidase, and the subsequent primary accumulation of undegraded heparan sulfate (HS). Respiratory pathology is considered secondary in MPS IIIA and the mechanisms are not well understood.